In order to show that a relationship does exist between the location of brain damage during stroke and the subsequent occurrence of depression, the results of 48 studies had to be grouped according to the meta-analysis methodology (which combines the results of several studies to make a single one whose numbers are much larger).

A slight difference is noted depending on the brain locations studied. Thus, reaching the right hemisphere slightly favors depressions (risk multiplied by 1.05), as well as reaching the anterior zones (risk multiplied by 1.17). The relationship between localization and depression seems to be confirmed, but the figures obtained above all point to the need to undertake other research.